ANTIBODY - THE FLEXIBLE ADAPTER MOLECULE

被引：78

作者：

BURTON, DR

机构：

[1] Krebs Institute, Department of Molecular Biology, The University, Sheffield

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 02期

关键词：

D O I：

10.1016/0968-0004(90)90178-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antibodies are flexible adaptor molecules linking target and potential killer i.e. antigen and effector. With the discovery of effector binding sites on antibodies we can begin to visualize at the molecular level how this adaptor role is fulfilled. © 1990.

引用

页码：64 / 69

页数：6

共 29 条

[21] CRYSTALLOGRAPHIC REFINEMENT AND ATOMIC MODELS OF THE INTACT IMMUNOGLOBULIN MOLECULE KOL AND ITS ANTIGEN-BINDING FRAGMENT AT 3.0-A AND 1.9-A RESOLUTION
MARQUART, M
DEISENHOFER, J
HUBER, R
PALM, W
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1980, 141 (04) : 369 - 391
[22] Metzger H, 1978, Contemp Top Mol Immunol, V7, P119
[23] A MODEL OF THE FC OF IMMUNOGLOBULIN-E
PADLAN, EA
DAVIES, DR
[J]. MOLECULAR IMMUNOLOGY, 1986, 23 (10) : 1063 - 1075
[24] THE USE OF ANTI-IGG MONOCLONAL-ANTIBODIES IN MAPPING THE MONOCYTE RECEPTOR-SITE ON IGG
PARTRIDGE, LJ
WOOF, JM
JEFFERIS, R
BURTON, DR
[J]. MOLECULAR IMMUNOLOGY, 1986, 23 (12) : 1365 - 1372
[25] REIDLER J, 1986, HDB EXPT IMMUNOLOGY, pCH17
[26] STRUCTURE AND FUNCTION OF HUMAN AND MURINE RECEPTORS FOR IGG
UNKELESS, JC
SCIGLIANO, E
FREEDMAN, VH
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1988, 6 : 251 - 281
[27] THE B-CELL BINDING-SITE ON HUMAN IMMUNOGLOBULIN-E
VERCELLI, D
HELM, B
MARSH, P
PADLAN, E
GEHA, RS
GOULD, H
[J]. NATURE, 1989, 338 (6217) : 649 - 651
[28] STRUCTURE OF THE HEMAGGLUTININ MEMBRANE GLYCOPROTEIN OF INFLUENZA-VIRUS AT 3-A RESOLUTION
WILSON, IA
SKEHEL, JJ
WILEY, DC
[J]. NATURE, 1981, 289 (5796) : 366 - 373
[29] LOCALIZATION OF THE MONOCYTE-BINDING REGION ON HUMAN IMMUNOGLOBULIN-G
WOOF, JM
PARTRIDGE, LJ
JEFFERIS, R
BURTON, DR
[J]. MOLECULAR IMMUNOLOGY, 1986, 23 (03) : 319 - 330

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