SITE-DEPENDENT AND TEST-DEPENDENT ANTINOCICEPTIVE EFFICACY OF AMITRIPTYLINE IN RATS

被引:19
作者
DIRKSEN, R [1 ]
VANDIEJEN, D [1 ]
VANLUIJTELAAR, ELJM [1 ]
BOOIJ, LHDJ [1 ]
机构
[1] UNIV NIJMEGEN, DEPT PSYCHOL, 6500 HB NIJMEGEN, NETHERLANDS
关键词
AMITRIPTYLINE; INTRATHECAL; INTRAVENOUS; INTRACEREBROVENTRICULAR; ANTINOCICEPTION; PAIN; RAT;
D O I
10.1016/0091-3057(94)90106-6
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The antinociceptive efficacy of systemic- (IV), spinal- (IT), and global supraspinal (ICV)-administered amitriptyline (AMIT) was compared in three different tests for nociception: the hot-plate test, the tail-flick test, and the withdrawal reflex test. Systemic AMIT inhibited the responses in each of the three tests, with distinct dose-effect relationships. Spinal AMIT reduced in a dose-dependent fashion the force of withdrawal to noxious electrical stimulation but was ineffective in the hot-plate test and facilitated the responses in the tail-flick test. Supraspinal AMIT inhibited in a dose-dependent fashion the response to the stimulus of the hot plate, reduced the force of withdrawal after a dose that was effective by the IV route, and again facilitated the responses in the tail-flick test. The results suggest that spinal sites mediate the inhibition of the withdrawal reflex and the supraspinal site the inhibition of the hot-plate test. Two conclusion are drawn: First, AMIT's site of action varies among the pain modalities; and, second, augmentation of the reactions can occur. The complex interaction accords with the clinical experience that the benefits of AMIT in pain treatment are hard to predict.
引用
收藏
页码:21 / 26
页数:6
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