ZINC CONTENT IN DISCRETE HIPPOCAMPAL AND AMYGDALOID AREAS OF THE EPILEPSY (EL) MOUSE AND NORMAL MICE

被引：32

作者：

FUKAHORI, M ^{[1
]}

ITOH, M ^{[1
]}

OOMAGARI, K ^{[1
]}

KAWASAKI, H ^{[1
]}

机构：

[1] KYUSHU UNIV, FAC MED, DEPT NEUROPSYCHIAT, MAIDASHI 3-1-1, FUKUOKA 812, JAPAN

来源：

BRAIN RESEARCH | 1988年 / 455卷 / 02期

关键词：

D O I：

10.1016/0006-8993(88)90099-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present study, zinc content was determined in discrete hippocampal and amygdaloid areas of 3 strains of mice (El, ddY and CBA) using an atomic absorption spectrophotometer. Zinc content was significantly lower in the dentate area of E1 strain compared to ddY and CBA strains. The El mouse is considered an animal model for epilepsy and the seizures in this mouse appear to originate in the hippocampus. The results suggest the possible involvment of hippocampal zinc in the pathophysiology of convulsive seizures in the epileptic mouse.

引用

页码：381 / 384

页数：4

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