STANDARD REFERENCE SPECTRA FOR TANDEM MASS-SPECTROMETRY QUALITY ASSURANCE, PERFORMANCE EVALUATION AND PROFICIENCY TESTING - TANDEM MASS SPECTROMETERS WHICH USE RF-ONLY MULTIPOLE COLLISION CELLS

The collisionally activated dissociation (CAD) of the acetone cation (m/z 58) can be used for quality assurance, performance evaluation, and proficiency testing of CAD measurements in tandem mass spectrometry (MS/MS) instruments which use RF-only multipole collision cells. The absolute branching ratios (product distributions) of the CAD fragment ions, when measured as a function of the center-of-mass collision energy E(cm), can provide an objective basis for quality assurance whenever MS/MS methods are used (viz, to validate how well the target thickness, ion-containment efficiency, and collision energy are being controlled in various instruments).