INHIBITION OF SIMIAN IMMUNODEFICIENCY VIRUS (SIV) REPLICATION BY CD8(+) CELLS OF SIV-INFECTED RHESUS MACAQUES - IMPLICATIONS FOR IMMUNOPATHOGENESIS

被引：15

作者：

BLACKBOURN, DJ ^{[1
]}

CHUANG, LF ^{[1
]}

KILLAM, KF ^{[1
]}

CHUANG, RY ^{[1
]}

机构：

[1] LAWRENCE LIVERMORE NATL LAB,SCH MED,DEPT MED PHARMACOL & TOXICOL,DAVIS,CA 95616

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1994年 / 23卷 / 06期

关键词：

CD8(+) SUPPRESSOR; SIVMAC INFECTION; TARGET CELL LYSIS; MACACA MULATTA;

D O I：

10.1111/j.1600-0684.1994.tb00297.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The ability of the CD8+ cells from simian immunodeficiency virus (SIV)-infected rhesus macaques to inhibit SIV replication was investigated. Inhibition was produced by a heat-stable soluble factor of molecular size greater than 10kDa. CD8+ supernatants from some macaques were found not only to suppress SIV growth but also to be cytolytic toward both infected and uninfected CD4+ cells. Such indiscriminate CD8+ cell-mediated cell killing may therefore account for DC4+ cell depletion in certain SIV-infected macaques.

引用

页码：343 / 354

页数：12

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