GM1 AND NGF SYNERGISM ON CHOLINE-ACETYLTRANSFERASE AND CHOLINE UPTAKE IN AGED BRAIN

被引：21

作者：

FONG, TG

VOGELSBERG, V

NEFF, NH

HADJICONSTANTINOU, M

机构：

[1] OHIO STATE UNIV, COLL MED, DEPT PSYCHIAT, COLUMBUS, OH 43210 USA

[2] OHIO STATE UNIV, COLL MED, DEPT PHARMACOL, COLUMBUS, OH 43210 USA

[3] OHIO STATE UNIV, COLL MED, PROGRAM NEUROSCI, COLUMBUS, OH 43210 USA

来源：

NEUROBIOLOGY OF AGING | 1995年 / 16卷 / 06期

关键词：

GM1; GANGLIOSIDE; NERVE GROWTH FACTOR; CHOLINE ACETYLTRANSFERASE; HIGH AFFINITY CHOLINE UPTAKE; AGED ANIMALS; SYNERGISM;

D O I：

10.1016/0197-4580(95)00088-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

In the brain of aged rats high affinity choline uptake (HAChU) of the striatum, hippocampus, and frontal cortex is lower than in young rats, while choline acetyltransferase (ChAT) activity is lower in striatum and frontal cortex. Infusion into the lateral cerebral ventricle with nerve growth factor (NGF) enhances the low values of these cholinergic markers in a dose- and region-dependent manner. GM1 ganglioside infused into the lateral ventricle, at a dose that is ineffective alone, together with NGF synergistically enhances the effect of NGF on ChAT and HAChU activities in the brain of aged animals. The pharmacology of this GM1/NGF synergism suggests potentiation of response.

引用

页码：917 / 923

页数：7

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