The Role of the Innate Immune System in Sepsis

被引：8

作者：

Censoplano, Nina ^{[1
]}

Epting, Conrad L. ^{[1
,2
]}

Coates, Bria M. ^{[1
]}

机构：

[1] Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med, Dept Pediat,Div Crit Care, Chicago, IL 60611 USA

[2] Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med, Dept Pathol,Div Crit Care, Chicago, IL 60611 USA

来源：

CLINICAL PEDIATRIC EMERGENCY MEDICINE | 2014年 / 15卷 / 02期

关键词：

sepsis; innate immune system; pattern recognition receptors; toll-like receptors; immunotherapy; cytokines; chemokines; complement; endothelium;

D O I：

10.1016/j.cpem.2014.04.007

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

Sepsis is a clinical syndrome characterized by activation of the host inflammatory system in response to infection. The initial phase, manifested by shock, fever, and hypermetabolism, is largely secondary to a hyperinflammatory state and is responsible for the classic signs and symptoms of early sepsis. This review focuses on the early events after infection, offering an overview of the innate immune response in the sepsis syndrome, and concludes with a discussion of immune-targeted therapies.

引用

页码：169 / 176

页数：8

共 70 条

[1]

Toll-like receptors: critical proteins linking innate and acquired immunity [J].