The Immune Response: Targets for the Treatment of Severe Sepsis

被引：9

作者：

Bernard, Mine M. ^{[1
,2
]}

Bernard, Gordon R. ^{[3
]}

机构：

[1] Univ Colorado, Sch Med, Dept Pediat, Div Crit Care, Aurora, CO 80045 USA

[2] Childrens Hosp Colorado, Div Pediat Crit Care, Aurora, CO 80045 USA

[3] Vanderbilt Univ, Sch Med, Med Ctr North, Dept Med,Div Allergy Pulm & Crit Care Med, Room T-1208, Nashville, TN 37232 USA

来源：

INTERNATIONAL JOURNAL OF INFLAMMATION | 2012年 / 2012卷

关键词：

D O I：

10.1155/2012/697592

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The clinical process of severe sepsis is characterized by extreme inflammation interlinked with potent stimulation of the coagulation cascade often followed by a state of relative immune paralysis. In this paper, we will review many of the potential therapies directed at various steps along the inflammatory cascade from modulation of inflammatory mediators eliciting the immune response, alteration of the host's immune response in both a stimulatory and depressive manner, and taming the overexuberant coagulation response triggered by the fierce coagulation-inflammation cycle. Finally, we will discuss further opportunities for research to improve our ability to design effective therapies.

引用

页数：9

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