PREVALENCE OF ANTIBODY TO HEPATITIS-C VIRUS IN JAPANESE SCHOOLCHILDREN - COMPARISON WITH ADULT-BLOOD DONORS

被引:56
作者
TANAKA, E
KIYOSAWA, K
SODEYAMA, T
HAYATA, T
OHIKE, Y
NAKANO, Y
YOSHIZAWA, K
FURUTA, S
WATANABE, Y
WATANABE, I
NISHIOKA, K
机构
[1] SHINSHU UNIV,SCH MED,DEPT INTERNAL MED 2,3-1-1 ASAHI,MATSUMOTO,NAGANO 390,JAPAN
[2] KISO PUBL HLTH CTR NAGANO PREFECTURE,KISOFUKUSHIMA 397,JAPAN
[3] JAPANESE RED CROSS CENT BLOOD CTR,TOKYO 150,JAPAN
关键词
D O I
10.4269/ajtmh.1992.46.460
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
A total of 1,442 schoolchildren in the Matsumoto City area were investigated for the prevalence of hepatitis virus-related serum markers, including antibody to hepatitis C virus (anti-HCV) and an abnormal serum transaminase level. Despite the large number of children tested, none was positive for anti-HCV antibodies or had been diagnosed as having viral hepatitis. The prevalence of anti-HCV antibodies in children and adult blood donors in the same area increased significantly with age from 0% in the 6-15-year-old group to 1.14% in the 50-65-year-old group (P < 0.00 1). Our results indicate that even if only the enzyme-linked immunosorbent assay results confirmed by the recombinant immunoblot assay are considered positive, the prevalence in children is significantly lower than that in blood donors (P < 0.05). Six children were healthy carriers of hepatitis B virus (HBV); all had been born to carrier mothers. These results indicate that apparently healthy schoolchildren in Japan have a low exposure to HCV infection.
引用
收藏
页码:460 / 464
页数:5
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    WONG, DC
    DIWAN, AR
    ROSEN, L
    GERIN, JL
    JOHNSON, RG
    POLITO, A
    PURCELL, RH
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