POTENTIAL ANTIMALARIALS .9. DI-MANNICH BASES OF 4-(7'-TRIFLUORO-METHYLQUINAZOLIN-4'-YLAMINO)PHENOL AND 4-(7'-TRIFLUOROMETHYLQUINOLIN-4'-YLAMINO)PHENOL

被引：2

作者：

BARLIN, GB

JIRAVINYU, C

机构：

[1] Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1990年 / 43卷 / 02期

关键词：

D O I：

10.1071/CH9900311

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Syntheses are reported for a series of di-Mannich bases of 4-(7′-trifluoromethylquinazolin-4′-ylamino)phenol derived from 4-chloro-7-trifluoromethylquinazoline with the di-Mannich bases of 4-aminophenol. Some analogous quinolines were prepared similarly. When tested for antimalarial activity against Plasmodium falciparum in vitro, the quinazolines were rather less active than the corresponding quinolines. © 1990 ASEG.

引用

页码：311 / 319

页数：9

共 12 条

[1] QUINAZOLINES .4. COVALENT HYDRATION IN CATIONS OF SUBSTITUTED QUINAZOLINES [J].

ARMAREGO, WL .

JOURNAL OF THE CHEMICAL SOCIETY, 1962, (FEB) :561-&

[2] QUINAZOLINES .9. COVALENT HYDRATION IN NEUTRAL SPECIES OF SUBSTITUTED QUINAZOLINES [J].

ARMAREGO, WL ;

SMITH, JIC .

JOURNAL OF THE CHEMICAL SOCIETY B-PHYSICAL ORGANIC, 1967, (05) :449-+

[3] POTENTIAL ANTIMALARIALS .7. DI-MANNICH BASES OF 4-[(7'-TRIFLUOROMETHYLQUINOLIN-4'-YL)-AMINOPHENOL AND 4-(7'-BROMO-1',5'-NAPHTHYRIDIN-4'-YL)]-AMINOPHENOL VIA 4-NITROPHENOLS [J].

BARLIN, GB ;

IRELAND, SJ .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1988, 41 (11) :1727-1733

[4] POTENTIAL ANTIMALARIALS .8. MONO-MANNICH AND DI-MANNICH BASES OF 2-(7-'-TRIFLUORO-METHYLQUINOLIN-4-'-YLAMINO)PHENOL VIA 2-NITROPHENOLS [J].

BARLIN, GB ;

YAN, JH .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1989, 42 (12) :2191-2199

[5] POTENTIAL ANTIMALARIALS .5. 4-(7'-TRIFLUOROMETHYLQUINOLIN-4'-YLAMINO)PHENOLS, 4-[2',7' AND 2',8'-BIS(TRIFLUOROMETHYL)QUINOLIN-4'-YLAMINO]PHENOLS AND N-4-SUBSTITUTED 2,7-(AND 2,8-)BIS(TRIFLUOROMETHYL)-QUINOLIN-4-AMINES [J].

BARLIN, GB ;

TAN, WL .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1985, 38 (12) :1827-1835

[6] POTENTIAL ANTIMALARIALS .6. MANNICH-BASES DERIVED FROM 4-[7'-BROMO(AND CHLORO)-1',5'-NAPHTHYRIDIN-4'-YLAMINO]PHENOLS AND 4-(7'-TRIFLUOROMETHYLQUINOLIN-4'-YLAMINO)PHENOL [J].

BARLIN, GB ;

TAN, WL .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1986, 39 (01) :51-57

[7] THE SYNTHESIS OF SOME TRIFLUOROMETHYL DERIVATIVES OF PARA-AMINOBENZOIC ACID, SULFANILAMIDE AND PARA,PARA'-DIAMINO DIPHENYL SULFONE [J].

CALDWELL, WT ;

SAYIN, AN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1951, 73 (11) :5125-5127

[8] TRIFLUOROMETHYL DERIVATIVES OF HYDROXYBENZOIC ACIDS AND RELATED COMPOUNDS [J].

HAUPTSCHEIN, M ;

NODIFF, EA ;

SAGGIOMO, AJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1954, 76 (04) :1051-1054

[9] 8-HYDROXY-5-TRIFLUOROMETHYLQUINOLINE [J].

PETTIT, MR ;

TATLOW, JC .

JOURNAL OF THE CHEMICAL SOCIETY, 1954, (NOV) :3852-3854

[10] THE INVITRO AND INVIVO ANTIMALARIAL ACTIVITY OF SOME MANNICH-BASES DERIVED FROM 4-[7'-BROMO (AND CHLORO)-1',5'-NAPHTHYRIDIN-4'-YLAMINO]PHENOL AND 4-(7'-TRIFLUOROMETHYLQUINOLIN-4'-YLAMINO)PHENOL [J].

SCOTT, HV ;

TAN, WL ;

BARLIN, GB .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1988, 82 (02) :127-134

← 1 2 →