COMPARISON OF THE BODY WALL MYOSIN HEAVY-CHAIN SEQUENCES FROM ONCHOCERCA-VOLVULUS AND BRUGIA-MALAYI

被引：12

作者：

WERNER, C

RAJAN, TV

机构：

[1] UNIV CONNECTICUT, CTR HLTH, DEPT PATHOL, FARMINGTON, CT 06030 USA

[2] UNIV CONNECTICUT, CTR HLTH, DEPT MICROBIOL, FARMINGTON, CT 06032 USA

[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT MICROBIOL & IMMUNOL, BRONX, NY 10461 USA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1992年 / 50卷 / 02期

关键词：

ONCHOCERCA-VOLVULUS; BRUGIA-MALAYI; DNA SEQUENCE; MYOSIN;

D O I：

10.1016/0166-6851(92)90222-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The complete coding sequence of Onchocerca volvulus myosin heavy chain has been determined from a series of overlapping cDNAs. The protein sequences from the 2 filarids, one responsible for subcutaneous filariasis, the other for lymphatic filariasis, show 92% identity, and are 1957 amino acids long. Each protein sequence is also equally related, with 75% identity, to MHC-B, the protein encoded by the unc-54 gene of the free-living nematode C. elegans. Such analysis is useful in phylogenetic studies among nematodes, as well as in structure-function relationships among myosin isolates.

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页码：255 / 260

页数：6

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