A CONCISE TOTAL SYNTHESIS OF C(14)-C(15) METHYLENE-BRIDGED EQUILENIN DERIVATIVES

被引：4

作者：

KUNZER, H

THIEL, M

机构：

[1] Research Laboratories, Schering AG-Berlin, 13342 Berlin

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 15期

关键词：

D O I：

10.1016/0040-4039(94)85211-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A five-step reaction sequence including hydroxyl group-assisted cyclopropanation, C(17)-oxidation, B-ring aromatization, C(17)-reduction, and methyl ether cleavage has been devised to convert 2 into 12. The synthesis of 19 took advantage of a facile isomerization of vinyl(benzyl)cyclopropane derivatives 6-11 into the corresponding beta-bridged analogues 13-18 over molecular sieves.

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页码：2329 / 2330

页数：2

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