RECEPTOR CLONING AND HETEROLOGOUS EXPRESSION - TOWARDS A NEW TOOL FOR DRUG DISCOVERY

被引：16

作者：

LUYTEN, WHML

LEYSEN, JE

机构：

[1] Department of Biochemical Pharmacology, Janssen Research Foundation, B2340 Beerse

来源：

TRENDS IN BIOTECHNOLOGY | 1993年 / 11卷 / 06期

关键词：

D O I：

10.1016/0167-7799(93)90136-W

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The explosion in the number of cloned receptors presents the pharmaceutical industry with challenges to discover new drugs targeting those receptors; to find more-selective drugs for all novel receptor subtypes; and to learn more about the function of the receptors in order to discern the conditions where such drugs may be applied usefully as therapeutics. At the same time, receptor cloning affords an unprecedented opportunity to address these challenges: heterologously expressed recombinant human receptors can be used for drug screening and - through an improved understanding of structure-function relationship - possibly for drug design, while the receptor clones permit mobilization of the full power of molecular biology to elucidate the function of the receptors in health and disease.

引用

页码：247 / 254

页数：8

共 74 条

[31]

JONSSON U, 1991, BIOTECHNIQUES, V11, P620

[32] CONTROL OF YEAST MATING SIGNAL TRANSDUCTION BY A MAMMALIAN BETA-2-ADRENERGIC RECEPTOR AND GS ALPHA-SUBUNIT [J].