5HT DRUGS IN ANIMAL-MODELS OF ANXIETY

被引:224
作者
HANDLEY, SL
MCBLANE, JW
机构
[1] Pharmaceutical Sciences Institute, Aston University, Gosta Green, B4 7ET, Birmingham
关键词
5HT; ANXIETY; ANIMAL MODEL;
D O I
10.1007/BF02247358
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
It has been widely accepted that 5HT neurones promote anxiety, in humans as well as in animal models. This could be termed the ''classic'' hypothesis and it has led to a determined search for drugs which reduce 5HT function, especially agents which have selective actions at 5HT receptor subtypes. However, these novel agents tend to have weak and/or variable effects in animal models and more detailed examination of their actions suggests that not all findings are accounted for by the classic hypothesis. There. appear to be circumstances in which increased 5HT activity can reduce anxious behaviour. There is increasing evidence for multiple anxiety mechanisms, which may be able to explain differential patterns of drug effects within and between models. Animal models of anxiety may also detect non-anxiety factors: effects on cognition or on impulsivity could be reflected in some models. This could be important in the light of recent evidence that 5HT-selective reuptake inhibitors are effective in impulsivity disorders. The classic hypothesis of 5HT function in anxiety may be only one part of an increasingly complex story. Unravelling the rest of this story is likely to lead to new insights in our understanding of anxiety and related disorders.
引用
收藏
页码:13 / 20
页数:8
相关论文
共 100 条
[1]   DECREASED REACTIVITY TO ANXIOLYTICS CAUSED BY EARLY PROTEIN-MALNUTRITION IN RATS [J].
ALMEIDA, SS ;
DEOLIVEIRA, LM ;
GRAEFF, FG .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 36 (04) :997-1000
[2]   MICROINJECTION OF PROPRANOLOL INTO THE DORSAL PERIAQUEDUCTAL GRAY CAUSES AN ANXIOLYTIC EFFECT IN THE ELEVATED PLUS-MAZE ANTAGONIZED BY RITANSERIN [J].
AUDI, EA ;
DEOLIVEIRA, RMW ;
GRAEFF, FG .
PSYCHOPHARMACOLOGY, 1991, 105 (04) :553-557
[3]   ATTENUATION OF CHEMICALLY-INDUCED DEFENSE RESPONSE BY 5-HT(1) RECEPTOR AGONISTS ADMINISTERED INTO THE PERIAQUEDUCTAL GRAY [J].
BECKETT, SRG ;
LAWRENCE, AJ ;
MARSDEN, CA ;
MARSHALL, PW .
PSYCHOPHARMACOLOGY, 1992, 108 (1-2) :110-114
[4]   ELECTROPHYSIOLOGICAL INVESTIGATION OF THE ADAPTIVE RESPONSE OF THE 5-HT SYSTEM TO THE ADMINISTRATION OF 5-HT1A RECEPTOR AGONISTS [J].
BLIER, P ;
DEMONTIGNY, C .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1990, 15 :S42-S48
[5]  
BOCKAERT J, 1987, N-S ARCH PHARMACOL, V335, P588
[6]   PROPOSALS FOR THE CLASSIFICATION AND NOMENCLATURE OF FUNCTIONAL RECEPTORS FOR 5-HYDROXYTRYPTAMINE [J].
BRADLEY, PB ;
ENGEL, G ;
FENIUK, W ;
FOZARD, JR ;
HUMPHREY, PPA ;
MIDDLEMISS, DN ;
MYLECHARANE, EJ ;
RICHARDSON, BP ;
SAXENA, PR .
NEUROPHARMACOLOGY, 1986, 25 (06) :563-576
[7]  
CADOGAN AK, 1992, NEUROSCI LETT S, V42, pS8
[8]   THE INFLUENCE OF RITANSERIN, A SEROTONIN ANTAGONIST, IN ANXIETY DISORDERS - A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY VERSUS LORAZEPAM [J].
CEULEMANS, DLS ;
HOPPENBROUWERS, MLJA ;
GELDERS, YG ;
REYNTJENS, AJM .
PHARMACOPSYCHIATRY, 1985, 18 (05) :303-305
[9]   SEROTONIN FUNCTION IN ANXIETY .2. EFFECTS OF THE SEROTONIN AGONIST MCPP IN PANIC DISORDER PATIENTS AND HEALTHY-SUBJECTS [J].
CHARNEY, DS ;
WOODS, SW ;
GOODMAN, WK ;
HENINGER, GR .
PSYCHOPHARMACOLOGY, 1987, 92 (01) :14-24
[10]   THE EFFECT OF INTRAVENOUS L-TRYPTOPHAN ON PROLACTIN AND GROWTH-HORMONE AND MOOD IN HEALTHY-SUBJECTS [J].
CHARNEY, DS ;
HENINGER, GR ;
REINHARD, JF ;
STERNBERG, DE ;
HAFSTEAD, KM .
PSYCHOPHARMACOLOGY, 1982, 77 (03) :217-222