A HUMAN ANTICARDIOLIPIN AUTOANTIBODY IS ENCODED BY DEVELOPMENTALLY RESTRICTED HEAVY AND LIGHT CHAIN VARIABLE REGION GENES

被引：33

作者：

SIMINOVITCH, KA

MISENER, V

KWONG, PC

YANG, PM

LASKIN, CA

CAIRNS, E

BELL, D

RUBIN, LA

CHEN, PP

机构：

[1] Department of Medicine, University of Toronto, Toronto, ON

[2] Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, La Jolla, CA, 92037

[3] Department of Medicine, University of Western Ontario, London, ON

来源：

AUTOIMMUNITY | 1990年 / 8卷 / 02期

关键词：

AUTOANTIBODY; ANTICARDIOLIPIN ANTIBODY; NATURAL AUTOIMMUNITY; IMMUNE REPERTOIRE; REPERTOIRE RESTRICTION; VARIABLE GENE USAGE;

D O I：

10.3109/08916939008995727

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Based on recent structural analyses of monoclonal autoantibodies, it appears that a number of these antibodies express germ-line immunoglobulin variable region (V) genes with little or no somatic mutation. In addition, our group and others have noted the identity or near identity of some autoantibody-associated V genes to V genes apparently expressed preferentially in the fetal pre-B cell repertoire. To extend these data, we now report that the heavy and light chain V genes of an anti-cardiolipin antibody derived from a healthy individual display 99% nucleotide sequence homology with V genes expressed in early B cell ontogeny. Sequence comparisons indicate the likely use of fetal-restricted V genes by this autoantibody. Taken together with other data on autoantibody V gene usage, these findings provide further evidence for overlap between the autoantibody-associated and early ontogeny expressed V gene repertoires and suggest that natural autoreactivity may be instrumental in the development and maintenance of the normal immune repertoire. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：97 / 105

页数：9

共 62 条

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