TRYPANOTHIONE METABOLISM AND RATIONAL APPROACHES TO DRUG DESIGN

被引：22

作者：

FAIRLAMB, AH

机构：

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 1990年 / 18卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1042/bst0180717

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：717 / 720

页数：4

共 35 条

[1] INHIBITION OF GLUTATHIONE SYNTHESIS AS A CHEMOTHERAPEUTIC STRATEGY FOR TRYPANOSOMIASIS [J].

ARRICK, BA ;

GRIFFITH, OW ;

CERAMI, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1981, 153 (03) :720-725

[2]

Bacchi C.J., 1987, P317

[3] BIOCHEMICAL-CHANGES ASSOCIATED WITH ALPHA-DIFLUOROMETHYLORNITHINE UPTAKE AND RESISTANCE IN TRYPANOSOMA-BRUCEI [J].

BELLOFATTO, V ;

FAIRLAMB, AH ;

HENDERSON, GB ;

CROSS, GAM .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1987, 25 (03) :227-238

[4] CHARACTERIZATION OF TRYPANOSOMA-BRUCEI-BRUCEI S-ADENOSYL-L-METHIONINE DECARBOXYLASE AND ITS INHIBITION BY BERENIL, PENTAMIDINE AND METHYLGLYOXAL BIS(GUANYLHYDRAZONE) [J].

BITONTI, AJ ;

DUMONT, JA ;

MCCANN, PP .

BIOCHEMICAL JOURNAL, 1986, 237 (03) :685-689

[5] DEFICIENT METABOLIC UTILIZATION OF HYDROGEN-PEROXIDE IN TRYPANOSOMA-CRUZI [J].

BOVERIS, A ;

SIES, H ;

MARTINO, EE ;

DOCAMPO, R ;

TURRENS, JF ;

STOPPANI, OM .

BIOCHEMICAL JOURNAL, 1980, 188 (03) :643-648

[6]

DOCAMPO R, 1986, FED PROC, V45, P2471

[7] NOVEL BIOCHEMICAL PATHWAYS IN PARASITIC PROTOZOA [J].

FAIRLAMB, AH .

PARASITOLOGY, 1989, 99 :S93-S112

[8] INVIVO EFFECTS OF DIFLUOROMETHYLORNITHINE ON TRYPANOTHIONE AND POLYAMINE LEVELS IN BLOOD-STREAM FORMS OF TRYPANOSOMA-BRUCEI [J].

FAIRLAMB, AH ;

HENDERSON, GB ;

BACCHI, CJ ;

CERAMI, A .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1987, 24 (02) :185-191

[9] IDENTIFICATION OF A NOVEL, THIOL-CONTAINING COFACTOR ESSENTIAL FOR GLUTATHIONE-REDUCTASE ENZYME-ACTIVITY IN TRYPANOSOMATIDS [J].

FAIRLAMB, AH ;

CERAMI, A .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1985, 14 (02) :187-198

[10] TRYPANOTHIONE - A NOVEL BIS(GLUTATHIONYL)SPERMIDINE COFACTOR FOR GLUTATHIONE-REDUCTASE IN TRYPANOSOMATIDS [J].

FAIRLAMB, AH ;

BLACKBURN, P ;

ULRICH, P ;

CHAIT, BT ;

CERAMI, A .

SCIENCE, 1985, 227 (4693) :1485-1487

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