DOSE-RESPONSE EFFECTS OF DIETARY GAMMA-LINOLENIC ACID ENRICHED OILS ON HUMAN POLYMORPHONUCLEAR-NEUTROPHIL BIOSYNTHESIS OF LEUKOTRIENE-B4

被引：66

作者：

ZIBOH, VA ^{[1
]}

FLETCHER, MP ^{[1
]}

机构：

[1] UNIV CALIF DAVIS, SCH MED, DEPT INTERNAL MED, DAVIS, CA 95616 USA

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1992年 / 55卷 / 01期

关键词：

GAMMA-LINOLENIC ACID; DIHOMO-GAMMA-LINOLENIC ACID; POLYMORPHONUCLEAR CELLS; PHOSPHOLIPIDS (PHOSPHATIDYLCHOLINE AND PHOSPHATIDYLETHANOLAMINE); LEUKOTRIENE-B4; BORAGE OIL; BLACK-CURRANT OIL;

D O I：

10.1093/ajcn/55.1.39

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The dose-dependent effect of dietary supplemented gamma-linolenic acid (GLA, 18:3n-6)-enriched borage oil (Bor) and black-currant oil on the ability of calcium ionophore-activated human polymorphonuclear neutrophils (PMN) to generate leukotriene B4 (LTB4) was investigated in adult healthy human volunteers. Significant (P < 0.05) elevation of dihomo-gamma-linolenic acid (DGLA, 20:3n-6), an elongation product of GLA, was revealed in PMN phospholipids after ingestion of either 0.48 or 1.5 g GLA-enriched oil/d. This elevation of DGLA in the PMN phospholipids paralleled the decreased capacity of calcium ionophore-activated PMN to generate LTB4. Although the inhibition of LTB4 was greater with the ingestion of 1.5 g GLA-enriched BOR/d, it was not significantly different from the ingestion of 0.48 g/d. Taken together, dietary ingestion of GLA-fortified oils does modulate PMN generation of proinflammatory LTB4.

引用

页码：39 / 45

页数：7

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