SERUM PROGESTERONE CONCENTRATIONS ON THE DAY AFTER HUMAN CHORIONIC-GONADOTROPIN ADMINISTRATION AND PROGESTERONE OOCYTE RATIOS PREDICT IN-VITRO FERTILIZATION-EMBRYO TRANSFER OUTCOME

被引：25

作者：

BURNS, WN

WITZ, CA

KLEIN, NA

SILVERBERG, KM

SCHENKEN, RS

机构：

[1] Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, 78284-7836, Texas

[2] Department of Obstetrics and Gynecology, University of Washington, Seattle, 98195, Washington

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 1994年 / 11卷 / 01期

关键词：

SERUM PROGESTERONE; DAY AFTER HUMAN CHORIONIC GONADOTROPIN ADMINISTRATION; PROGESTERONE OOCYTE RATIO; IN-VITRO FERTILIZATION; PREGNANCY RATE;

D O I：

10.1007/BF02213692

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose: In gonadotropin-releasing hormone analogue-pretreated in vitro fertilization-embryo transfer cycles, pregnancy rates are inversely related to serum progesterone levels on the day of administration of human chorionic gonadotropin. The relationship of the progesterone concentration on other days in the periovulatory period to pregnancy rates in such cycles is little studied. We therefore retrospectively analyzed the relationship between progesterone concentrations on the day after human chorionic gonadotropin and pregnancy in 114 cycles, 28 and 23 of which produced clinical and ongoing/delivered pregnancies, respectively. To assess the effect of the extent of follicular luteinization on success, we also studied the relationship between the progesterone concentration per oocyte retrieved and pregnancy for the day of and day after human chorionic gonadotropin. Results: Progesterone concentrations on the day after human chorionic gonadotropin were inversely associated with clinical pregnancy by multiple logistic regression analysis (P < 0.05). Progesterone/oocyte ratios were inversely associated with clinical pregnancy (P < 0.05) and ongoing/delivered pregnancy (P < 0.02) for both the day of and the day after human chorionic gonadotropin. Conclusion: The study results extend the window of time during which elevated progesterone concentration is associated with poor outcome to at least 2 days. This finding is consistent with hypothetical mechanisms attributing the link between progesterone concentration and outcome to either endometrial or follicle/oocyte events. The association of lack of follicular luteinization (low progesterone per oocyte ratios) and favorable outcome suggests a predominant effect of progesterone on follicle/oocyte quality. Further studies are needed to clarify the mechanisms underlying the association between progesterone and in vitro fertilization-embryo transfer outcome.

引用

页码：17 / 23

页数：7

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