PROFOUND AND POSSIBLY PRIMARY IDIOPATHIC CD4(+) T-LYMPHOCYTOPENIA IN A PATIENT WITH FUNGAL-INFECTIONS

被引：10

作者：

SELIGMANN, M

AUTRAN, B

RABIAN, C

FERCHAL, F

OLIVE, D

ECHARD, M

OKSENHENDLER, E

机构：

[1] HOP ST LOUIS,VIROL LAB,PARIS,FRANCE

[2] HOP LA PITIE SALPETRIERE,CELLULAR IMMUNOL LAB,PARIS,FRANCE

[3] INSERM,U119,MARSEILLE,FRANCE

[4] HOP MONTFERMEIL,DEPT INTERNAL MED,MONTFERMEIL,FRANCE

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1994年 / 71卷 / 02期

关键词：

D O I：

10.1006/clin.1994.1073

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A profound and long-lasting reduction in circulating CD4(+) T lymphocytes (<80/mu l) was found in a 37-year-old man (without known risk factors for HIV infection) presenting with recurrent oral candidiasis who subsequently developed cryptococcal meningitis. Infection with HIV was ruled out by serological and virological studies. In vitro and in vivo cell-mediated immunity was severely impaired. Abnormal phenotypic patterns of both CD4(+) and CD8(+) cells were consistently observed. A systematic family survey revealed in some of his asymptomatic relatives several immunological abnormalities which may point to a genetically based primary immunodeficiency disorder. (C) 1994 Academic Press, Inc.

引用

页码：203 / 207

页数：5