2 NEW CYTOTOXIC CHALCONES FROM CALYTHROPSIS-AUREA

被引：18

作者：

BEUTLER, JA

CARDELLINA, JH

GRAY, GN

PRATHER, TR

SHOEMAKER, RH

BOYD, MR

LIN, CM

HAMEL, E

CRAGG, GM

机构：

[1] NCI,DIV CANC TREATMENT,DRUG DISCOVERY RES & DEV LAB,FREDERICK,MD 21702

[2] NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,NAT PROD BRANCH,FREDERICK,MD 21702

[3] NCI,DIV CANC TREATMENT,MOLEC PHARMACOL LAB,FREDERICK,MD 21702

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 10期

关键词：

D O I：

10.1021/np50100a009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The crude extract of Calythropsis aurea (Myrtaceae) produced a pattern of differential cytotoxicity in the NCI 60 cell line assay which was similar to those of known tubulin-interactive compounds. Cytotoxicity-guided fractionation led to the isolation of two new chalcones, calythropsin [1] and dihydrocalythropsin (2], which were responsible for the activity. Calythropsin was demonstrated to have a weak effect on mitosis, and presumably also on tubulin polymerization.

引用

页码：1718 / 1722

页数：5

共 9 条

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