SELENIUM IN THE MAINTENANCE AND THERAPY OF HIV-INFECTED PATIENTS

被引:50
作者
SCHRAUZER, GN
SACHER, J
机构
[1] University of California, San Diego, Department of Chemistry and Biochemistry, La Jolla
[2] Große Friedberger Str.
关键词
SELENIUM; THERAPY; HIV;
D O I
10.1016/0009-2797(94)90040-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Due to its antiviral effects and its importance for all immunological functions, the administration of selenium is suggested as a supportive measure in early as well as in advanced stages of HIV-induced disease. Initial observations on the effects of selenium supplementation in HIV-infected patients indicate that selenium causes symptomatic improvements and possibly slows the course of the disease. As selenium inhibits reverse transcriptase activity in RNA-virus-infected animals, supplemental selenium could also prevent the replication of HIV and retard the development of AIDS in newly HIV-infected subjects. An adequate supply of selenium and of antioxidant vitamins is also proposed as a measure to reduce the probability of the placental transmission of HIV in pregnancy.
引用
收藏
页码:199 / 205
页数:7
相关论文
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