FECAL SHEDDING OF CLOSTRIDIUM-DIFFICILE IN DOGS - A PERIOD PREVALENCE SURVEY IN A VETERINARY MEDICAL TEACHING HOSPITAL

被引：48

作者：

STRUBLE, AL

TANG, YJ

KASS, PH

GUMERLOCK, PH

MADEWELL, BR

SILVA, J

机构：

[1] Department of Veterinary Surgical and Radiological Sciences, University of California, Davis

[2] Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis

[3] Molecular Research Laboratory, Department of Internal Medicine, School of Medicine, University of California, Davis

来源：

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION | 1994年 / 6卷 / 03期

关键词：

D O I：

10.1177/104063879400600310

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The goal of this study was to determine the fecal prevalence of Clostridium difficile in dogs who were patients at a veterinary medical teaching hospital. Stool specimens collected from 152 dogs (in- and outpatients) were analyzed for the presence of C. difficile. An additional 42 stool specimens were collected and examined from dogs recently housed at local animal shelters. Following culture on selective medium, C. difficile was identified by a latex agglutination test, and the presence of the toxin A and B was determined individually by polymerase chain reaction. Clostridium difficile was isolated from the feces of 28 of the veterinary hospital patients (18.4%); isolates from 14 of these patients (50.0%) were toxigenic. Diarrhea was a clinical finding in 5 (35.7%) of the dogs carrying toxigenic isolates of C. difficile, whereas diarrhea was noted in only 2 of 14 dogs (14.3%) shedding nontoxigenic isolates. Three of 14 dogs (21.4%) shedding toxigenic isolates of C. difficile were receiving antibiotics at the time of stool collection, whereas 5 of 14 dogs (37.5%) shedding non-toxigenic strains of C. difficile were receiving antibiotics. The carriage rate of C. difficile was significantly higher for animals categorized as inpatients of the veterinary hospital. The carriage rate also provided evidence for an increased risk for fecal shedding with increasing age. Clostridium difficile was not isolated from any of the 42 dogs recently housed at local animal shelters. This study confirms the presence of toxigenic C. difficile in dogs at a veterinary teaching hospital. Additional studies will be required to determine whether prior antibiotic treatment increases the frequency of C. difficile fecal shedding from dogs and whether colonized dogs are a risk for transmission of the organism to susceptible human populations.

引用

页码：342 / 347

页数：6

共 20 条

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