SYSTEMIC AND LOCAL IMMUNE-RESPONSES TO ENHANCED-POTENCY INACTIVATED POLIOVIRUS VACCINE IN PREMATURE AND TERM INFANTS

被引:37
作者
ADENYIJONES, SCA
FADEN, H
FERDON, MB
KWONG, MS
OGRA, PL
机构
[1] CHILDRENS HOSP BUFFALO, DIV INFECT DIS, 219 BRYANT ST, BUFFALO, NY 14222 USA
[2] THOMAS JEFFERSON UNIV, DEPT PEDIAT, DIV NEONATOL, PHILADELPHIA, PA 19107 USA
[3] SUNY BUFFALO, SCH MED, DEPT PEDIAT, DIV NEONATOL, BUFFALO, NY 14214 USA
[4] SUNY BUFFALO, SCH MED, DIV INFECT DIS, BUFFALO, NY 14214 USA
[5] UNIV TEXAS, MED BRANCH, DEPT PEDIAT, GALVESTON, TX 77550 USA
关键词
D O I
10.1016/S0022-3476(05)80228-8
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Serum neutralizing, nasopharyngeal neutralizing, and IgA antibodies to polioviruses 1, 2, and 3 were detected in preterm and term infants who had received three doses of an enhanced-potency inactivated Poliovirus vaccine at 2,4, and 12 months of age. After the third dose of this vaccine, 95% or more of the infants tested had detectable serum neutralizing antibodies to polioviruses types 1, 2, and 3. Nasopharyngeal neutralizing and IgA antibodies were defected in 43% to 91% of the infants. The peak geometric mean titers of serum and nasopharyngeal antibodies against polioviruses types 1, 2, and 3 were similar for both groups. These preliminary data indicate that preterm infants are capable of mounting systemic and local immune responses to enhanced-potency inactivated poliovirus vaccine that are comparable to those made by term infants.
引用
收藏
页码:686 / 689
页数:4
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