INTERLEUKIN-1 SYSTEM IN THE MATERNO-TROPHOBLAST UNIT IN HUMAN IMPLANTATION - IMMUNOHISTOCHEMICAL EVIDENCE FOR AUTOCRINE/PARACRINE FUNCTION

被引:162
作者
SIMON, C
FRANCES, A
PIQUETTE, G
HENDRICKSON, M
MILKI, A
POLAN, ML
机构
[1] STANFORD UNIV, MED CTR, DEPT PATHOL, STANFORD, CA 94305 USA
[2] STANFORD UNIV, MED CTR, DEPT OBSTET, STANFORD, CA 94305 USA
[3] STANFORD UNIV, MED CTR, DEPT GYNECOL, STANFORD, CA 94305 USA
关键词
D O I
10.1210/jc.78.4.847
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Interleukin-1 receptor type I, IL-1 beta, IL-1 receptor antagonist, and human macrophages were immunohistochemically localized in the villous trophoblast, maternal-trophoblast interphase, and maternal decidua during early human implantation. Immunostaining for IL-1 receptor type I was present in the syncytiotrophoblast and hyperplastic endometrial glands in the maternal decidua. Immunoreactive IL-1 beta was present in the villous cytotrophoblast, syncytiotrophoblast, intermediate trophoblast, and maternal stromal decidual cells. IL-1 receptor antagonist staining was observed in the glandular endometrium of the maternal decidua and in isolated cells located inside the chorionic villi, intervillous space, and maternal decidua. Mature human macrophages, as defined by both CD/68(+) and HAM56(+), were present in the chorionic villi, maternal blood of intervillous space, and maternal decidua. Colocalization studies demonstrated that macrophages in all of the reported locations also stained for immunoreactive IL-1 beta. Our results show the shared presence in maternal and embryonic tissues of this receptor-agonist-antagonist system during early human implantation. This finding supports an autocrine/paracrine role for the IL-1 system in human implantation.
引用
收藏
页码:847 / 854
页数:8
相关论文
共 27 条
[1]  
Baranao R.I., 1992, FERTIL STERIL S, V58
[2]   BIOLOGY OF INTERLEUKIN-1 [J].
DINARELLO, CA .
FASEB JOURNAL, 1988, 2 (02) :108-115
[3]   THE CELL-SURFACE RECEPTORS FOR INTERLEUKIN-1-ALPHA AND INTERLEUKIN-1-BETA ARE IDENTICAL [J].
DOWER, SK ;
KRONHEIM, SR ;
HOPP, TP ;
CANTRELL, M ;
DEELEY, M ;
GILLIS, S ;
HENNEY, CS ;
URDAL, DL .
NATURE, 1986, 324 (6094) :266-268
[4]   PLACENTAL MONONUCLEAR PHAGOCYTES AS A SOURCE OF INTERLEUKIN-1 [J].
FLYNN, A ;
FINKE, JH ;
HILFIKER, ML .
SCIENCE, 1982, 218 (4571) :475-477
[5]   MORPHOLOGICAL-CHANGES OF THE SPIRAL ARTERIES IN THE PLACENTAL BED IN RELATION TO PRE-ECLAMPSIA AND FETAL GROWTH-RETARDATION [J].
GERRETSEN, G ;
HUISJES, HJ ;
ELEMA, JD .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1981, 88 (09) :876-881
[6]   INTERLEUKIN-1 RECEPTOR ANTAGONIST ACTIVITY OF A HUMAN INTERLEUKIN-1 INHIBITOR [J].
HANNUM, CH ;
WILCOX, CJ ;
AREND, WP ;
JOSLIN, FG ;
DRIPPS, DJ ;
HEIMDAL, PL ;
ARMES, LG ;
SOMMER, A ;
EISENBERG, SP ;
THOMPSON, RC .
NATURE, 1990, 343 (6256) :336-340
[7]   EPIDERMAL GROWTH-FACTOR AND ITS RECEPTOR IN HUMAN IMPLANTATION TROPHOBLAST - IMMUNOHISTOCHEMICAL EVIDENCE FOR AUTOCRINE PARACRINE FUNCTION [J].
HOFMANN, GE ;
DREWS, MR ;
SCOTT, RT ;
NAVOT, D ;
HELLER, D ;
DELIGDISCH, L .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 74 (05) :981-988
[8]   THE INTERLEUKIN-1 RECEPTOR IN RAJI HUMAN B-LYMPHOMA CELLS - MOLECULAR CHARACTERIZATION AND EVIDENCE FOR RECEPTOR-MEDIATED ACTIVATION OF GENE-EXPRESSION [J].
HORUK, R ;
MCCUBREY, JA .
BIOCHEMICAL JOURNAL, 1989, 260 (03) :657-663
[9]   DIFFERENTIAL DISTRIBUTION OF INTERLEUKIN-1-ALPHA AND INTERLEUKIN-1-ALPHA PROTEINS IN HUMAN PLACENTAS [J].
HU, XL ;
YANG, YP ;
HUNT, JS .
JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 1992, 22 (03) :257-268
[10]   INTERLEUKIN-1-BETA, HUMAN-LEUKOCYTE ANTIGEN HLA-DR-ALPHA, AND TRANSFORMING GROWTH-FACTOR-BETA EXPRESSION IN ENDOMETRIUM, PLACENTA, AND PLACENTAL MEMBRANES [J].
KAUMA, S ;
MATT, D ;
STROM, S ;
EIERMAN, D ;
TURNER, T .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 163 (05) :1430-1437