ALTERED REGULATION OF INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-I IN PATIENTS WITH POLYCYSTIC-OVARY-SYNDROME

被引:17
作者
CARMINA, E
STANCZYK, FZ
MORRIS, RS
LEE, PDK
SAVJANI, G
LOBO, RA
机构
[1] UNIV SO CALIF, SCH MED, DEPT OBSTET & GYNECOL, DIV REPROD ENDOCRINOL & INFERTIL, LOS ANGELES, CA USA
[2] UNIV PALERMO, CATTEDRA ENDOCRINOL, PALERMO, ITALY
[3] DIAGNOST SYST LABS INC, WEBSTER, TX USA
关键词
INSULIN-LIKE GROWTH FACTOR BINDING-PROTEIN 1; POLYCYSTIC OVARY SYNDROME;
D O I
10.1016/1071-5576(95)94690-V
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: Insulin-like growth factor (IGF-I) action is influenced by circulating as well as tissue levels of its binding proteins. Because sevum IGF binding protein-1 (IGFBP-1) levels have been found to be decreased in patients with polycystic ovary syndrome (PCOS), we tested the hypothesis that regulation of IGFBP-1 secretion may be different inpatients with PCOS compared with normal women. METHODS: We studied 15 normal ovulatory women and 15 women with PCOS of similar age (21 +/- 1 and 22 +/- 1 years, respectively). All subjects were studied after an overnight fast between days 5-8 after spontaneous or progestin-induced menses. Perturbations included the administration of insulin intravenously, maintenance of a euglycemic clamp, and, in a subsequent cycle, the administration of a long-acting somatostatin analogue (octreotide, 100 mu g) given subcutaneously. Blood samples were collected before treatment, every 15 minutes for 6 hours after insulin, and every 30 minutes for 3 hours after octreotide administration. Serum levels of IGF-I, IGFBP-1, IGFBP-3, and insulin were measured by specific immunoassays. RESULTS: Compared with the controls, patients with PCOS had significantly higher insulin levels, similar IGF-I and IGFBP-3 levels, and significantly lower IGFBP-1. Insulin did not change serum IGF-I levels in either group, although a significant decrease in IGFBP-1 levels occurred in normal women but nor in patients with PCOS. Octreotide treatment also did not change serum IGF-I levels in either group, but serum insulin levels decreased significantly and IGFBP-1 levels increased significantly in both groups; this response was significantly greater in controls. CONCLUSION: Our data ave compatible with the notion that regulation of IGFBP-1 is altered in women with PCOS and that several factors may be involved.
引用
收藏
页码:743 / 747
页数:5
相关论文
共 33 条
[1]   POTENTIAL RELEVANCE OF INSULIN-LIKE GROWTH FACTOR-I TO OVARIAN PHYSIOLOGY - FROM BASIC SCIENCE TO CLINICAL-APPLICATION [J].
ADASHI, EY ;
RESNICK, CE ;
HERNANDEZ, ER ;
SVOBODA, ME ;
VANWYK, JJ .
SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY, 1989, 7 (01) :94-99
[2]   INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 INHIBITS THE DNA AMPLIFICATION INDUCED BY INSULIN-LIKE GROWTH FACTOR-I IN HUMAN GRANULOSA LUTEAL CELLS [J].
ANGERVO, M ;
KOISTINEN, R ;
SUIKKARI, AM ;
SEPPALA, M .
HUMAN REPRODUCTION, 1991, 6 (06) :770-773
[3]  
BARBIERI RL, 1988, FERTIL STERIL, V50, P197
[4]   INSULIN REGULATION OF INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 IN OBESE AND NONOBESE HUMANS [J].
CONOVER, CA ;
LEE, PDK ;
KANALEY, JA ;
CLARKSON, JT ;
JENSEN, MD .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 74 (06) :1355-1360
[5]   INSULIN REGULATION OF INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-PRODUCTION IN CULTURED HEPG2 CELLS [J].
CONOVER, CA ;
LEE, PDK .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (04) :1062-1067
[6]   LACK OF GROWTH-HORMONE EFFECT ON INSULIN-ASSOCIATED SUPPRESSION OF INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 IN HUMANS [J].
CONOVER, CA ;
BUTLER, PC ;
WANG, M ;
RIZZA, RA ;
LEE, PDK .
DIABETES, 1990, 39 (10) :1251-1256
[7]   SUPPRESSION OF ENDOGENOUS INSULIN-SECRETION REGULATES THE RAPID RISE OF INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEIN (IGFBP)-1 LEVELS FOLLOWING ACUTE HYPOGLYCEMIA [J].
COTTERILL, AM ;
HOLLY, JMP ;
AMIEL, S ;
WASS, JAH .
CLINICAL ENDOCRINOLOGY, 1993, 38 (06) :633-639
[8]   RECOMBINANT HUMAN INSULIN-LIKE GROWTH-FACTOR (IGF)-BINDING PROTEIN-1 INHIBITS SOMATIC GROWTH STIMULATED BY IGF-I AND GROWTH-HORMONE IN HYPOPHYSECTOMIZED RATS [J].
COX, GN ;
MCDERMOTT, MJ ;
MERKEL, E ;
STROH, CA ;
KO, SC ;
SQUIRES, CH ;
GLEASON, TM ;
RUSSELL, D .
ENDOCRINOLOGY, 1994, 135 (05) :1913-1920
[9]   INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II - PEPTIDE, MESSENGER RIBONUCLEIC-ACID AND GENE STRUCTURES, SERUM, AND TISSUE CONCENTRATIONS [J].
DAUGHADAY, WH ;
ROTWEIN, P .
ENDOCRINE REVIEWS, 1989, 10 (01) :68-91
[10]   A COMPARISON OF FOLLICULAR-FLUID LEVELS OF INSULIN-LIKE GROWTH FACTOR-I IN NORMAL DOMINANT AND COHORT FOLLICLES, POLYCYSTIC AND MULTICYSTIC OVARIES [J].
EDEN, JA ;
JONES, J ;
CARTER, GD ;
ALAGHBANDZADEH, J .
CLINICAL ENDOCRINOLOGY, 1988, 29 (03) :327-336