INHIBITION OF HUMAN ACUTE LYMPHOBLASTIC-LEUKEMIA CELLS BY IMMUNOTOXINS - POTENTIATION BY CHLOROQUINE

被引：124

作者：

RAMAKRISHNAN, S ^{[1
]}

HOUSTON, LL ^{[1
]}

机构：

[1] UNIV KANSAS, DEPT BIOCHEM, LAWRENCE, KS 66045 USA

来源：

SCIENCE | 1984年 / 223卷 / 4631期

关键词：

D O I：

10.1126/science.6318313

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immunotoxins containing pokeweed antiviral protein and monoclonal antibodies against human T cells or human transferrin receptor efficiently killed acute lymphoblastic leukemia cells. Chloroquine specifically enhanced the rate of protein synthesis inhibition by immunotoxin. Depending on its concentration, chloroquine (10-100 .mu.M) reduced by up to 65-fold the amount of immunotoxin required to inhibit protein synthesis in the target cells 50%. [Chloroquine appears to enhance cellular binding and uptake of immunotoxins.].

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页码：58 / 61

页数：4

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