INTERACTION OF CHOLINERGIC AND GLUTAMATERGIC TRANSMISSION IN THE HIPPOCAMPUS - AN INVITRO AUTORADIOGRAPHIC RECEPTOR ANALYSIS

Quantitative in vitro receptor autoradiography was used to examine the effect of acute scopolamine administration on specific binding to components of the N-methyl-d-aspartate (NMDA) receptor complex in four regions of mouse hippocampus. The binding of [3H]glycine to the strychine-insensitive site was increased 1 h after administration of scopolamine hydrobromide (10 mg/kg) in the ventral dentate gyrus. The study suggests that rapid alterations in strychnine-insensitive glycine binding can occur in response to cholinergic perturbations. Moreover, these data suggest a delicate interaction between cholinergic and glutamatergic projections in the hippocampus. © 1990.