MOLECULAR-CLONING, SEQUENCE-ANALYSIS AND EXPRESSION OF A CDNA-ENCODING HUMAN TYPE-1 ANGIOTENSIN-II RECEPTOR

被引：107

作者：

TAKAYANAGI, R ^{[1
]}

OHNAKA, K ^{[1
]}

SAKAI, Y ^{[1
]}

NAKAO, R ^{[1
]}

YANASE, T ^{[1
]}

HAJI, M ^{[1
]}

INAGAMI, T ^{[1
]}

FURUTA, H ^{[1
]}

GOU, DF ^{[1
]}

NAKAMUTA, M ^{[1
]}

NAWATA, H ^{[1
]}

机构：

[1] VANDERBILT UNIV,MED CTR,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90570-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We isolated a cDNA encoding type-1 angiotensin II receptor from a human liver cDNA library. The cDNA had an open reading frame encoding a protein of 359 amino acid residues with a relative Mr of 41,060. The deduced amino acid sequence of the human angiotensin II (Ang II) receptor was 95.3% and 94.2% identical to those of bovine and rat type-1 Ang II receptors, respectively, and had a significant similarity with the G protein-coupled receptor. The rank order of the binding to the receptor expressed in COS-7 cells was Ang II > Ang III > Ang I. The expression of the Ang II receptor mRNA was detected in human liver, lung, adrenal and adrenocortical adenomas but not in adrenomedullary tumor, pheochromocytoma, by Northern blot analysis. © 1992.

引用

页码：910 / 916

页数：7

共 17 条

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