INDUCTION OF CHROMOSOME CHANGES BY METAL-COMPOUNDS IN CULTURED CHO CELLS

被引：28

作者：

HOWARD, W ^{[1
]}

LEONARD, B ^{[1
]}

MOODY, W ^{[1
]}

KOCHHAR, TS ^{[1
]}

机构：

[1] KENTUCKY STATE UNIV,DIV MATH & SCI,FRANKFORT,KY 40601

来源：

TOXICOLOGY LETTERS | 1991年 / 56卷 / 1-2期

关键词：

CHROMOSOME ABERRATIONS; SISTER CHROMATID EXCHANGE; 5-BROMO-2'-DEOXYURIDINE; CHO CELLS;

D O I：

10.1016/0378-4274(91)90105-F

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The effect of 4 metal salts on the induction of chromosome aberrations and sister chromatid exchange (SCE) in cultured Chinese hamster ovary (CHO) cells was investigated. It was observed that CdCl2, NiCl2, CrO3 and HgCl2 were effective in causing various types of chromosome aberrations. The percentages of abnormalities increased with increasing doses of the metals used. These metal compounds also raised the SCE rates compared to 5-bromo-2'-deoxyuridine controls. The importance of rapid screening of potentially hazardous metals is described.

引用

页码：179 / 186

页数：8

共 22 条

[11] EFFECTS OF POLYCYCLIC-HYDROCARBONS ON THE INDUCTION OF CHROMOSOMAL-ABERRATIONS IN ABSENCE OF AN EXOGENOUS METABOLIC-ACTIVATION SYSTEM IN CULTURED HAMSTER-CELLS [J].