THE EXVIVO EFFECT OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) ON RAT INTRANEURONAL AND EXTRANEURONAL MONOAMINE-OXIDASE ACTIVITY

被引：11

作者：

ARAI, Y

TOYOSHIMA, Y

KINEMUCHI, H

TADANO, T

KISARA, K

机构：

[1] SHOWA UNIV,SCH MED,DEPT PHARMACOL,1-5-8 HATANODAI,SHINAGAWA KU,TOKYO 142,JAPAN

[2] TOHOKU COLL PHARM,DEPT PHARMACOL,SENDAI,MIYAGI 983,JAPAN

来源：

NEUROSCIENCE LETTERS | 1986年 / 70卷 / 02期

关键词：

D O I：

10.1016/0304-3940(86)90475-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

引用

页码：266 / 271

页数：6

共 19 条

[1]

ARAI Y, 1985, BIOGENIC AMINES, V2, P65

[2] INHIBITION OF RAT-BRAIN MONOAMINE-OXIDASE BY SOME ANALOGS OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE AND 1-METHYL-4-PHENYLPYRIDINIUM ION [J].

ARAI, Y ;

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NEUROSCIENCE LETTERS, 1986, 66 (01) :43-48

[3]

ARAI Y, 1984, B JAPAN NEUROCHEM SO, V23, P454

[4] SELECTIVE-INHIBITION OF MONOAMINE-OXIDASE IN MONO-AMINERGIC NEURONS IN THE RAT-BRAIN [J].

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ROSS, SB .

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[5] POTENTIAL BIOACTIVATION PATHWAYS FOR THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) [J].

CASTAGNOLI, N ;

CHIBA, K ;

TREVOR, AJ .

LIFE SCIENCES, 1985, 36 (03) :225-230

[6] ACTIVE UPTAKE OF MPP+, A METABOLITE OF MPTP, BY BRAIN SYNAPTOSOMES [J].

CHIBA, K ;

TREVOR, AJ ;

CASTAGNOLI, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 128 (03) :1228-1232

[7]

FULLER RW, 1985, J PHARMACOL EXP THER, V232, P696

[8] EFFECTS OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE AND RELATED-COMPOUNDS ON THE UPTAKE OF [H-3]3,4-DIHYDROXYPHENYLETHYLAMINE AND [H-3]5-HYDROXYTRYPTAMINE IN NEOSTRIATAL SYNAPTOSOMAL PREPARATIONS [J].

HEIKKILA, RE ;

YOUNGSTER, SK ;

MANZINO, L ;

CABBAT, FS ;

DUVOISIN, RC .

JOURNAL OF NEUROCHEMISTRY, 1985, 44 (01) :310-313

[9] PARTICIPATION OF BRAIN MONOAMINE-OXIDASE B FORM IN THE NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE - RELATIONSHIP BETWEEN THE ENZYME-INHIBITION AND THE NEUROTOXICITY [J].

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ARAI, Y ;

TOYOSHIMA, Y .

NEUROSCIENCE LETTERS, 1985, 58 (02) :195-200

[10]

KINEMUCHI H, 1984, MONOAMINE OXIDASE DI, P53

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