EVIDENCE FOR A CHOLINERGIC PROJECTION FROM THE PEDUNCULOPONTINE TEGMENTAL NUCLEUS TO THE ROSTRAL VENTROLATERAL MEDULLA IN THE RAT

被引：76

作者：

YASUI, Y

CECHETTO, DF

SAPER, CB

机构：

[1] UNIV CHICAGO,DEPT PHARMACOL & PHYSIOL SCI,947 E 59TH ST,CHICAGO,IL 60637

[2] UNIV WESTERN ONTARIO,JOHN P ROBARTS INST,DEPT STROKE & AGING,LONDON N6A 5K8,ONTARIO,CANADA

[3] UNIV CHICAGO,DEPT NEUROL,CHICAGO,IL 60637

[4] UNIV CHICAGO,COMM NEUROBIOL,CHICAGO,IL 60637

[5] UNIV CHICAGO,BRAIN RES INST,CHICAGO,IL 60637

[6] UNIV WESTERN ONTARIO,DEPT PHYSIOL,LONDON N6A 5K8,ONTARIO,CANADA

来源：

BRAIN RESEARCH | 1990年 / 517卷 / 1-2期

关键词：

Blood pressure; Choline acetyltransferase; Laterodorsal tegmental nucleus; Pedunculopontine tegmental nucleus; Rostral ventrolateral medulla;

D O I：

10.1016/0006-8993(90)91002-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies indicate that cholinergic innervation of the rostral ventrolateral medulla (RVL) may play an important role in regulation of blood pressure, but the origin of this input is known. Using retrograde fluorescent tracing combined with immunohistochemistry for choline acetyltransferase, we found that as many as 10% of the cholinergic neurons in the pedunculopontine tegmental nucleus (PPT) can be retrogradely labeled from RVL. Anterograde tracing of this pathway with PHA-L demonstrated that descending fibers from the region of the PPT ramify and give off terminal boutons in the RVL. These studies indicate that PPT may be a major source of cholinergic afferents to the RVL. © 1990.

引用

页码：19 / 24

页数：6

共 16 条

[1] DISTRIBUTION OF CHOLINERGIC NEURONS IN RAT-BRAIN - DEMONSTRATED BY THE IMMUNOCYTOCHEMICAL LOCALIZATION OF CHOLINE-ACETYLTRANSFERASE [J].