THE ANTISTEROID RU486 - ITS CELLULAR AND MOLECULAR-MODE OF ACTION

被引：73

作者：

BAULIEU, EE

机构：

[1] Hormone Laboratory, INSERM U33

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1991年 / 2卷 / 06期

关键词：

D O I：

10.1016/1043-2760(91)90030-Q

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

RU486 is a very powerful antisteroid hormone compound, with antiprogestin and antiglucocorticosteroid clinical applications. High-affinity binding to the receptor ligand-binding domain results in essentially antagonistic function; however, some agonistlike effects have been observed. This review discusses the implications of recent discoveries concerning hsp90 (heat-shock protein M(r) approximately 90,000)-receptor interaction, receptor-DNA binding, and the involvement of transcription factors in the mechanism of action of RU486.

引用

页码：233 / 239

页数：7

共 24 条

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