AMYOTROPHIC-LATERAL-SCLEROSIS (ALS) - A PHYLOGENETIC DISEASE OF THE CORTICOMOTONEURON

被引：199

作者：

EISEN, A ^{[1
]}

KIM, S ^{[1
]}

PANT, B ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT MED,DIV NEUROL,VANCOUVER V6T 1W5,BC,CANADA

来源：

MUSCLE & NERVE | 1992年 / 15卷 / 02期

关键词：

AMYOTROPHIC LATERAL SCLEROSIS; CORTICOMOTONEURON; MOTONEURON;

D O I：

10.1002/mus.880150215

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It is proposed that the primary cell involved in amyotrophic lateral sclerosis (ALS) is the corticomotoneuron. The spinal motoneuron becomes affected as a result of antegrade effects. This hypothesis does not negate most of the presently popular theories regarding the pathogenesis of ALS, but directs focus to one cell type-the corticomotoneuron. It takes cognizance of the complex, monosynaptic, corticomotoneuronal-spinomotoneuronal connections that have evolved in primates, and especially in man. It might explain the lack of any natural or thus far induced animal model which closely mimics the human disease. Threshold measurements to transcotical magnetic stimulation might be used to test the hypothesis. Replication of ALS in an animal is only likely to succeed in a nonhuman primate.

引用

页码：219 / 224

页数：6

共 84 条

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