GROWTH-DIFFERENTIATION FACTOR-10 - A NEW MEMBER OF THE TRANSFORMING GROWTH-FACTOR-BETA SUPERFAMILY RELATED TO BONE MORPHOGENETIC PROTEIN-3

被引:90
作者
CUNNINGHAM, NS
JENKINS, NA
GILBERT, DJ
COPELAND, NG
REDDI, AH
LEE, SJ
机构
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT ORTHOPAED SURG,MUSCULOSKELETAL CELL BIOL LAB,BALTIMORE,MD 21205
[2] NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MAMMALIAN GENET LAB,FREDERICK,MD 21702
[3] JOHNS HOPKINS UNIV,SCH MED,DEPT MOLEC BIOL & GENET,BALTIMORE,MD 21205
关键词
GROWTH DIFFERENTIATION FACTOR; BONE MORPHOGENETIC PROTEIN-3;
D O I
10.3109/08977199509028956
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
We have identified a new member of the transforming growth factor-beta (TGF-beta) superfamily, growth/differentiation factor-10 (GDF-10), which is highly related to bone morphogenetic protein-3 (BMP-3). The nucleotide sequence of GDF-10 encodes a predicted protein of 476 amino acids with a molecular weight of approximately 52,000. The GDF-10 polypeptide contains a potential signal sequence for secretion, a putative RXXR proteolytic processing site, and a carboxy-terminal domain with considerable homology to other known members of the TGF-beta superfamily. In the mature carboxy-terminal domain GDF-10 is more homologous to BMP-3 (83% amino acid sequence identity) than to any other previously identified TGF-beta family member. GDF-10 also shows significant homology to BMP-3 (approximately 30% amino acid sequence identity) in the pro- region of the molecule. Based on these sequence comparisons, GDF-10 and BMP-3 define a new subgroup within the larger TGF-beta superfamily. By Northern analysis, GDF-10 mRNA was detected primarily in murine uterus, adipose tissue, and brain and to a lesser extent in liver and spleen. In addition, GDF-10 mRNA was present in both neonatal and adult bone samples, with higher levels being detected in calvaria than in long bone. These results suggest that GDF10 may play multiple roles in regulating cell differentiation events, including those involved in skeletal morphogenesis. Gdf10 was mapped to the proximal region of mouse chromosome 14 close to a region known to contain a spontaneous recessive mutation that is associated with a craniofacial defect.
引用
收藏
页码:99 / 109
页数:11
相关论文
共 50 条
[41]   DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS [J].
SANGER, F ;
NICKLEN, S ;
COULSON, AR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5463-5467
[42]   LIMB ALTERATIONS IN BRACHYPODISM MICE DUE TO MUTATIONS IN A NEW MEMBER OF THE TGF-BETA-SUPERFAMILY [J].
STORM, EE ;
HUYNH, TV ;
COPELAND, NG ;
JENKINS, NA ;
KINGSLEY, DM ;
LEE, SJ .
NATURE, 1994, 368 (6472) :639-643
[43]   BONE MORPHOGENETIC PROTEIN-2 STIMULATES ALKALINE-PHOSPHATASE ACTIVITY AND COLLAGEN-SYNTHESIS IN CULTURED OSTEOBLASTIC CELLS, MC3T3-E1 [J].
TAKUWA, Y ;
OHSE, C ;
WANG, EA ;
WOZNEY, JM ;
YAMASHITA, K .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 174 (01) :96-101
[44]  
TENDIJKE P, 1988, P NATL ACAD SCI USA, V85, P4715
[45]   IDENTIFICATION OF BMP-4 AS A SIGNAL MEDIATING SECONDARY INDUCTION BETWEEN EPITHELIAL AND MESENCHYMAL TISSUES DURING EARLY TOOTH DEVELOPMENT [J].
VAINIO, S ;
KARAVANOVA, I ;
JOWETT, A ;
THESLEFF, I .
CELL, 1993, 75 (01) :45-58
[46]   AUTORADIOGRAPHIC LOCALIZATION OF OSTEOGENIN BINDING-SITES IN CARTILAGE AND BONE DURING RAT EMBRYONIC-DEVELOPMENT [J].
VUKICEVIC, S ;
PARALKAR, VM ;
CUNNINGHAM, NS ;
GUTKIND, JS ;
REDDI, AH .
DEVELOPMENTAL BIOLOGY, 1990, 140 (01) :209-214
[47]   RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN INDUCES BONE-FORMATION [J].
WANG, EA ;
ROSEN, V ;
DALESSANDRO, JS ;
BAUDUY, M ;
CORDES, P ;
HARADA, T ;
ISRAEL, DI ;
HEWICK, RM ;
KERNS, KM ;
LAPAN, P ;
LUXENBERG, DP ;
MCQUAID, D ;
MOUTSATSOS, IK ;
NOVE, J ;
WOZNEY, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (06) :2220-2224
[48]   NOVEL REGULATORS OF BONE-FORMATION - MOLECULAR CLONES AND ACTIVITIES [J].
WOZNEY, JM ;
ROSEN, V ;
CELESTE, AJ ;
MITSOCK, LM ;
WHITTERS, MJ ;
KRIZ, RW ;
HEWICK, RM ;
WANG, EA .
SCIENCE, 1988, 242 (4885) :1528-1534
[49]   THE BONE MORPHOGENETIC PROTEIN FAMILY AND OSTEOGENESIS [J].
WOZNEY, JM .
MOLECULAR REPRODUCTION AND DEVELOPMENT, 1992, 32 (02) :160-167
[50]   NODAL IS A NOVEL TGF-BETA-LIKE GENE EXPRESSED IN THE MOUSE NODE DURING GASTRULATION [J].
ZHOU, XL ;
SASAKI, H ;
LOWE, L ;
HOGAN, BLM ;
KUEHN, MR .
NATURE, 1993, 361 (6412) :543-547