INCREASED TRANSCELLULAR PERMEABILITY OF RAT SMALL-INTESTINE AFTER THERMAL-INJURY

被引：26

作者：

CARTER, EA

GONNELLA, A

TOMPKINS, RG

机构：

[1] Pediatric Gastrointestinal and Nutritional Laboratory, Boston

[2] Massachusetts General Hospital, Boston

[3] Shriners Burns Institute, Boston

[4] Department of Pediatrics, Harvard Medical School, Boston

[5] Department of Surgery, Harvard Medical School, Boston

[6] Childrens Service, Boston Childrens Hospital, Boston

[7] Surgical Services, Massachusetts General Hospital, Boston

来源：

BURNS | 1992年 / 18卷 / 02期

关键词：

D O I：

10.1016/0305-4179(92)90007-H

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The pathway which results in a loss of intestinal barrier function and transepithelial transfer of macromolecules after cutaneous thermal injury is unknown. To determine the enhanced absorption pathway, transepithelial transport of horseradish peroxidase (HRP) was examined ultrastructurally after a thermal injury. Within 6 h after the injury, increased HRP uptake was seen in the portal and systemic blood with the maximal increase in uptake measured at 18 h postinjury; permeability returned to normal by 72 h postinjury. Morphologically, the increased uptake was found to be transcellular through ultrastructurally normal intestinal absorptive cells. Occasional focal regions of enhanced HRP uptake were found and this enhanced uptake was attributed to focal intestinal epithelial disruptions. This increase in intestinal permeability represents a transient loss of intestinal barrier function and potentially allows absorption of macromolecules such as endotoxin from the intestinal lumen into the portal circulation early after thermal injury.

引用

页码：117 / 120

页数：4

共 27 条

[11]

Jackson, Lessof, Baker, Et al., Intestinal permeability in patients with eczema and food allergy, The Lancet, 1, (1981)

[12]

Kingham, Baker, Loehry, Autoradiographic study of the permeability characteristics of the small intestine, Gut, 19, (1978)

[13]

Lewis, Fordtran, Effect of perfusion rate on absorption, surface area, unstirred water layer thickness, permeability, and intraluminal pressure in the rat ileum in vivo, Gastroenterology, 68, (1975)

[14]

Mochizuki, Trocki, Dominioni, Et al., Mechanism of prevention of postburn hypermetabolism and catabolism by early enteral feeding, Ann. Surg., 200, (1984)

[15]

Murphy, Eastham, Nelson, Et al., Intestinal permeability in Crohn's Disease, Arch. Dis. Child., 64, (1989)

[16]

O'Dwyer, Michie, Ziegler, Et al., A single dose of endotoxin increases intestinal permeability in healthy humans, Arch. Surg., 123, (1988)

[17]

Olaison, Leandersson, Sjodahl, Et al., Intestinal permeability to polyethyleneglycol 600 in Crohn's disease, Peroperative determination in a defined segment of the small intestine, 29, (1988)

[18]

Peled, Watz, Gilat, Measurement of intestinal permeability using <sup>51</sup>Cr-EDTA, Am. J. Gastroenterol., 80, (1985)

[19]

Pike, Heddle, Boulton, Et al., Increased permeability in atopic eczema, J. Invest. Dermatol., 86, (1986)

[20]

Rhodes, Kamovsky, Loss of macromolecular barrier function associated with surgical trauma to the intestine, Lab. Invest., 25, (1971)

← 1 2 3 →