IMIDAZOLE-ZINC CATALYSTS FOR RNA HYDROLYSIS

被引：59

作者：

CHU, FY ^{[1
]}

SMITH, J ^{[1
]}

LYNCH, VM ^{[1
]}

ANSLYN, EV ^{[1
]}

机构：

[1] UNIV TEXAS,DEPT CHEM & BIOCHEM,AUSTIN,TX 78712

来源：

INORGANIC CHEMISTRY | 1995年 / 34卷 / 22期

关键词：

D O I：

10.1021/ic00126a045

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Zinc-imidazole complexes are reported to enhance the rate of hydrolysis of RNA to nearly the same extent as zinc-amine complexes and zinc alone. The imidazole containing ligands are easily synthesized. Ligand 1 binds zinc with an association constant of (9 +/- 1) x 10(4) M(-1), and possesses a metal bound water with a pK(a) of 7.4 +/- 0.1. These zinc complexes should prove quite useful in elucidating the mechanism of Zn-OH-promoted RNA hydrolysis.

引用

页码：5689 / &

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