INTERLEUKIN-2 RECEPTOR GAMMA-CHAIN - A FUNCTIONAL COMPONENT OF THE INTERLEUKIN-4 RECEPTOR

被引：803

作者：

RUSSELL, SM

KEEGAN, AD

HARADA, N

NAKAMURA, Y

NOGUCHI, M

LELAND, P

FRIEDMANN, MC

MIYAJIMA, A

PURI, RK

PAUL, WE

LEONARD, WJ

机构：

[1] NHLBI,PULM & MOLEC IMMUNOL SECT,BETHESDA,MD 20892

[2] NIAID,IMMUNOL LAB,BETHESDA,MD 20892

[3] DNAX RES INST MOLEC & CELLULAR BIOL INC,PALO ALTO,CA 94304

[4] US FDA,CTR BIOL EVALUAT & RES,DIV CELLULAR & GENE THERAPIES,BETHESDA,MD 20892

来源：

SCIENCE | 1993年 / 262卷 / 5141期

关键词：

D O I：

10.1126/science.8266078

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The interleukin-2 (IL-2) receptor gamma chain (IL-2Rgamma) is an essential component of high- and intermediate-affinity IL-2 receptors. IL-2Rgamma was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL-2Rgamma to augment IL-4 binding affinity, and the requirement for IL-2Rgamma in IL-4-mediated phosphorylation of insulin receptor substrate-1. The observation that IL-2Rgamma is a functional component of the IL-4 receptor, together with the finding that IL-2Rgamma associates with the IL-7 receptor, begins to elucidate why deficiency of this common gamma chain (gamma(c)) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

引用

页码：1880 / 1883

页数：4

共 51 条

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