CONVERSION OF SERINE AND THREONINE RESIDUES INTO ALPHA-ACYLOXY-HALOGENOGLYCINE, ALPHA-ALKYLTHIO-HALOGENOGLYCINE, AND ALPHA-HALOGENOGLYCINE MOIETIES - A NEW STRATEGY FOR THE MODIFICATION OF PEPTIDES

被引：42

作者：

APITZ, G ^{[1
]}

STEGLICH, W ^{[1
]}

机构：

[1] UNIV BONN, INST ORGAN CHEM & BIOCHEM, GERHARD DOMAGK STR 1, W-5300 BONN 1, GERMANY

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(00)79711-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Selective modification of serine and threonine containing peptides is accomplished by oxidation with lead tetraacetate. Conversion of the derived alpha-acyloxyglycine derivatives into alpha-alkylthio- and alpha-halogenoglycine residues offers a novel synthetic route to modified glycyl peptides, enzyme inhibitors, and dehydropeptides.

引用

页码：3163 / 3166

页数：4

共 20 条

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