MULTIDRUG RESISTANCE

被引：197

作者：

PASTAN, I ^{[1
]}

GOTTESMAN, MM ^{[1
]}

机构：

[1] NCI,CELL BIOL LAB,BETHESDA,MD 20892

来源：

ANNUAL REVIEW OF MEDICINE | 1991年 / 42卷

关键词：

P-GLYCOPROTEIN; DOXORUBICIN; VINBLASTINE; CANCER; GENE THERAPY; VERAPAMIL;

D O I：

10.1146/annurev.med.42.1.277

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Laboratory investigations indicate that cancer cells can become simultaneously resistant to many different chemotherapeutic drugs that are natural products via the expression of an energy-dependent drug efflux pump. This multidrug transporter is a plasma membrane glycoprotein encoded in the human by the MDR1 gene. Recent clinical studies indicate that expression of the multidrug transporter plays a major role in the intrinsic and acquired resistance to chemotherapy of many human cancers. Strategies aimed at inactivating this drug efflux pump may have significant impact on the treatment of human cancer.

引用

收藏

页码：277 / 286

页数：10

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