MULTIDRUG RESISTANCE

被引：197

作者：

PASTAN, I ^{[1
]}

GOTTESMAN, MM ^{[1
]}

机构：

[1] NCI,CELL BIOL LAB,BETHESDA,MD 20892

来源：

ANNUAL REVIEW OF MEDICINE | 1991年 / 42卷

关键词：

P-GLYCOPROTEIN; DOXORUBICIN; VINBLASTINE; CANCER; GENE THERAPY; VERAPAMIL;

D O I：

10.1146/annurev.med.42.1.277

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Laboratory investigations indicate that cancer cells can become simultaneously resistant to many different chemotherapeutic drugs that are natural products via the expression of an energy-dependent drug efflux pump. This multidrug transporter is a plasma membrane glycoprotein encoded in the human by the MDR1 gene. Recent clinical studies indicate that expression of the multidrug transporter plays a major role in the intrinsic and acquired resistance to chemotherapy of many human cancers. Strategies aimed at inactivating this drug efflux pump may have significant impact on the treatment of human cancer.

引用

收藏

页码：277 / 286

页数：10

相关论文

共 25 条

[11] EXPRESSION OF A MULTIDRUG RESISTANCE GENE IN HUMAN CANCERS [J].

GOLDSTEIN, LJ ;

GALSKI, H ;

FOJO, A ;

WILLINGHAM, M ;

LAI, SL ;

GAZDAR, A ;

PIRKER, R ;

GREEN, A ;

CRIST, W ;

BRODEUR, GM ;

LIEBER, M ;

COSSMAN, J ;

GOTTESMAN, MM ;

PASTAN, I .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (02) :116-124

[12] EXPRESSION OF THE MULTIDRUG RESISTANCE, MDR1, GENE IN NEUROBLASTOMAS [J].

GOLDSTEIN, LJ ;

FOJO, AT ;

UEDA, K ;

CRIST, W ;

GREEN, A ;

BRODEUR, G ;

PASTAN, I ;

GOTTESMAN, MM .

JOURNAL OF CLINICAL ONCOLOGY, 1990, 8 (01) :128-136

[13]

GOTTESMAN MM, 1988, J BIOL CHEM, V263, P12163

[14] FUNCTIONAL-ROLE FOR THE 170-KDA TO 180-KDA GLYCOPROTEIN SPECIFIC TO DRUG-RESISTANT TUMOR-CELLS AS REVEALED BY MONOCLONAL-ANTIBODIES [J].

HAMADA, H ;

TSURUO, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (20) :7785-7789

[15] ATP-DEPENDENT TRANSPORT OF VINBLASTINE IN VESICLES FROM HUMAN MULTIDRUG-RESISTANT CELLS [J].

HORIO, M ;

GOTTESMAN, MM ;

PASTAN, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (10) :3580-3584

[16] MDR1 GENE-EXPRESSION IN LUNG-CANCER [J].

LAI, SL ;

GOLDSTEIN, LJ ;

GOTTESMAN, MM ;

PASTAN, I ;

TSAI, CM ;

JOHNSON, BE ;

MULSHINE, JL ;

IHDE, DC ;

KAYSER, K ;

GAZDAR, AF .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (15) :1144-1150

[17] REDUCED PERMEABILITY IN CHO-CELLS AS A MECHANISM OF RESISTANCE TO COLCHICINE [J].

LING, V ;

THOMPSON, LH .

JOURNAL OF CELLULAR PHYSIOLOGY, 1974, 83 (01) :103-116

[18] EXPRESSION OF A HUMAN COMPLEMENTARY-DNA FOR THE MULTIDRUG RESISTANCE GENE IN MURINE HEMATOPOIETIC PRECURSOR CELLS WITH THE USE OF RETROVIRAL GENE-TRANSFER [J].

MCLACHLIN, JR ;

EGLITIS, MA ;

UEDA, K ;

KANTOFF, PW ;

PASTAN, IH ;

ANDERSON, WF ;

GOTTESMAN, MM .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (15) :1260-1263

[19]

MICKISCH GH, 1990, IN PRESS P NATL ACAD

[20] A RETROVIRUS CARRYING AN MDR1 CDNA CONFERS MULTIDRUG RESISTANCE AND POLARIZED EXPRESSION OF P-GLYCOPROTEIN IN MDCK CELLS [J].

PASTAN, I ;

GOTTESMAN, MM ;

UEDA, K ;

LOVELACE, E ;

RUTHERFORD, AV ;

WILLINGHAM, MC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (12) :4486-4490