PURE AKINESIA - AN ATYPICAL MANIFESTATION OF PROGRESSIVE SUPRANUCLEAR PALSY

被引：85

作者：

MATSUO, H

TAKASHIMA, H

KISHIKAWA, M

KINOSHITA, I

MORI, M

TSUJIHATA, M

NAGATAKI, S

机构：

[1] NAGASAKI UNIV,SCH MED,DEPT INTERNAL MED 1,7-1 SAKAMOTO MACHI,NAGASAKI 852,JAPAN

[2] SCI DATA CTR ATOM BOMB DISASTER,DEPT PATHOL,NAGASAKI,JAPAN

[3] NATL NAGASAKI CHUO HOSP,DEPT NEUROL,OMURA,NAGASAKI,JAPAN

[4] ISAHAYA INSURANCE GEN HOSP,DEPT INTERNAL MED,ISAHAYA,JAPAN

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1991年 / 54卷 / 05期

关键词：

D O I：

10.1136/jnnp.54.5.397

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two patients with "pure akinesia" who showed the characteristic changes of progressive supranuclear palsy (PSP) at necropsy are described. They had akinesia but no rigidity or tremor, and ophthalmoplegia was not observed during the course of illness. The symptoms of "pure akinesia" was not improved by levodopa therapy but was considerably improved by L-threo-3,4-dihydroxyphenylserine. At necropsy, pathological findings were not different from those reported for PSP. It is suggested that "pure akinesia" is an atypical manifestation of PSP, and that norepinephrinergic neurons may be involved in some types of PSP.

引用

页码：397 / 400

页数：4