THROMBOMODULIN - BIOLOGY AND POTENTIAL CARDIOVASCULAR APPLICATIONS

被引：43

作者：

DITTMAN, WA ^{[1
]}

机构：

[1] DUKE UNIV,SCH MED,DURHAM,NC 27705

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1991年 / 1卷 / 08期

关键词：

D O I：

10.1016/1050-1738(91)90070-U

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombomodulin on endothelial surfaces is the major cofactor for the activation of the anticoagulant protein C by thrombin. Recent studies of the structure and regulation of thrombomodulin provide important clues as to its mechanism of action. These studies should enable the rational use of thrombomodulin as a therapeutic agent to inhibit coagulation either by infusion of thrombomodulin or its derivatives, or by pharmacologic alteration of cellular levels.

引用

页码：331 / 336

页数：6

共 43 条

[31] RODGERS GM, 1990, BLOOD, V75, P895
[32] A CONSERVED AU SEQUENCE FROM THE 3' UNTRANSLATED REGION OF GM-CSF MESSENGER-RNA MEDIATES SELECTIVE MESSENGER-RNA DEGRADATION
SHAW, G
KAMEN, R
[J]. CELL, 1986, 46 (05) : 659 - 667
[33] SOFF GA, 1991, BLOOD, V77, P515
[34] STEARNS DJ, 1989, J BIOL CHEM, V264, P3352
[35] STENFLO J, 1988, J BIOL CHEM, V263, P21
[36] SUZUKI K, 1989, J BIOL CHEM, V264, P4872
[37] TAKANO S, 1990, BLOOD, V76, P2024
[38] TANAKA A, 1991, CLIN CHEM, V37, P269
[39] PROTEIN-C PREVENTS THE COAGGULOPATHIC AND LETHAL EFFECTS OF ESCHERICHIA-COLI INFUSION IN THE BABOON
TAYLOR, FB
CHANG, A
ESMON, CT
DANGELO, A
VIGANODANGELO, S
BLICK, KE
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (03) : 918 - 925
[40] THOMPSON EA, 1988, THROMB HAEMOSTASIS, V59, P339

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