EXCITOTOXIC INCREASE OF XANTHINE DEHYDROGENASE AND XANTHINE-OXIDASE IN THE RAT OLFACTORY CORTEX

被引：14

作者：

BATTELLI, MG ^{[1
]}

BUONAMICI, L ^{[1
]}

ABBONDANZA, A ^{[1
]}

VIRGILI, M ^{[1
]}

CONTESTABILE, A ^{[1
]}

STIRPE, F ^{[1
]}

机构：

[1] UNIV BOLOGNA,DEPT BIOL,I-40126 BOLOGNA,ITALY

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1995年 / 86卷 / 1-2期

关键词：

EXCITOTOXICITY; FREE RADICAL; XANTHINE DEHYDROGENASE; XANTHINE OXIDASE; OLFACTORY CORTEX; HIPPOCAMPUS;

D O I：

10.1016/0165-3806(95)00012-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Excitotoxic lesions induced by systemic injection of kainic acid, resulted in 2-3-fold increase of xanthine dehydrogenase and xanthine oxidase activities in the rat olfactory cortex 48-72 h after drug administration. A significant increase of the xanthine oxidase/dehydrogenase ratio was also observed at 4 and 48 h post-injection. No similar changes were noticed in the hippocampus. The enhancement of enzyme activity seems to be primarily a consequence of the altered cell composition in damaged area. Free radicals produced by the increased oxygen-dependent form of the enzyme could in turn aggravate the excitotoxic brain injury.

引用

页码：340 / 344

页数：5

共 35 条

[1] EFFECTS OF HYPOXIA AND ETHANOL ON XANTHINE-OXIDASE OF ISOLATED RAT HEPATOCYTES - CONVERSION FROM D TO O FORM AND LEAKAGE FROM CELLS [J].