ENZYME-MEDIATED ENANTIOFACE-DIFFERENTIATING HYDROLYSIS OF ALPHA-SUBSTITUTED SULFUR-CONTAINING CYCLIC KETONE ENOL ESTERS

被引：21

作者：

KUME, Y ^{[1
]}

OHTA, H ^{[1
]}

机构：

[1] KEIO UNIV,DEPT CHEM,HIYOSHI 3-14-1,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 42期

关键词：

MICROBIAL HYDROLYSIS; ENOL ESTERS; TETRAHYDROTHIOPYRAN-4-ONE;

D O I：

10.1016/S0040-4039(00)60975-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enzymatic method for obtaining optically active alpha-substituted acyclic ketones is described. Pichia farinosa IAM 4682, a kind of yeast, hydrolyzed enol esters of sulfur-containing cyclic ketone with differentiation of the enantiotopic. face. The resulting ketone could be easily desulfurized to afford the corresponding acyclic ketone without loss of its optical purity.

引用

页码：6367 / 6370

页数：4

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