ROLE OF GROWTH-FACTORS IN DEGENERATION AND REGENERATION IN THE CENTRAL-NERVOUS-SYSTEM - CLINICAL-EXPERIENCES WITH NGF IN PARKINSONS AND ALZHEIMERS DISEASES

被引：51

作者：

OLSON, L

BACKMAN, L

EBENDAL, T

ERIKSDOTTERJONHAGEN, M

HOFFER, B

HUMPEL, C

FREEDMAN, R

GIACOBINI, M

MEYERSON, B

NORDBERG, A

SEIGER, A

STROMBERG, I

SYDOW, O

TOMAC, A

TROK, K

WINBLAD, B

机构：

[1] Department of Neuroscience, Karolinska Institute, Stockholm

来源：

JOURNAL OF NEUROLOGY | 1994年 / 242卷 / 01期

关键词：

D O I：

10.1007/BF00939233

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neurotrophin-mediated mechanisms are integral to development and maintenance of the adult central nervous system. Neurotrophin expression has been shown to change rapidly in response to many different types of neuronal stress such as excitotoxic injury, mechanical lesions, epileptogenesis and ischemia. It therefore appears as if they are not only to be regarded as target-derived trophic factors in the classical sense, but also as providers of local trophic support and neuronal protection. These discoveries suggest that neurotrophins or compounds with neurotrophin-like actions might become useful in developing new treatment strategies, not only for neurodegenerative diseases, but also for other diseases and injuries to the nervous system including stroke.

引用

页码：S12 / S15

页数：4