共 11 条
[11]
VRAY B, 1982, ADV EXP MED BIOL, V141, P567
EICOSANOIDS MODULATE CR-1-DEPENDENT AND FC-DEPENDENT BACTERIAL PHAGOCYTOSIS
被引：14
作者：
COQUETTE, A
BOEYNAEMS, JM
VRAY, B
机构：
[1] UNIV LIBRE BRUXELLES,IMMUNOL LAB,ROUTE LENNIK 808,B-1070 BRUSSELS,BELGIUM
[2] UNIV LIBRE BRUXELLES,FAC MED,INST RECH INTERDISCIPLINAIRE BIOL HUMAINE & NUCL,B-1070 BRUSSELS,BELGIUM
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION
|
1992年
/
226卷
/
01期
关键词：
PERITONEAL CELLS (RAT);
PHAGOCYTOSIS (BACTERIAL);
EICOSANOIDS;
INDOMETHACIN;
CR-1;
RECEPTORS;
FC RECEPTORS;
D O I：
10.1016/0922-4106(92)90075-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
It is known that macrophages produce large amounts of eicosanoids during phagocytosis and that pharmacological concentrations of prostaglandin E2 (PGE2) inhibit phagocytosis in several models. However, the physiological effect on phagocytosis of endogenous prostaglandins, produced during CRI- or FcR-mediated bacterial phagocytosis, remains unclear. In this study, we show that indomethacin inhibits the CR1- but not the FcR-dependent phagocytosis of bacteria by rat peritoneal cells in the same range of concentrations that inhibit the synthesis of PGE2, PGI2 and thromboxane A2. An exogenous supply of PGE2 and PGE1 (10(-10) to 10(-8) M) restored the CR1-mediated phagocytosis; higher concentrations were inhibitory. Our data indicate that PGE2 and/or PGI2. produced by rat peritoneal cells, are involved in CR1-dependent bacterial phagocytosis.
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页码：1 / 4
页数：4
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