MEASLES-VIRUS GLYCOPROTEINS - STUDIES ON THE STRUCTURE AND INTERACTION OF THE HEMAGGLUTININ AND FUSION PROTEINS

被引：74

作者：

MALVOISIN, E

WILD, TF

机构：

[1] Institut Pasteur de Lyon, Unite Immun. Strategie Vaccinale, 69365 Lyon Cedex 07, Avenue Tony-Garnier

来源：

JOURNAL OF GENERAL VIROLOGY | 1993年 / 74卷

关键词：

D O I：

10.1099/0022-1317-74-11-2365

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have investigated the structure and interaction of the measles virus (MV) glycoproteins expressed at the cell membrane. Cross-linking studies with a variety of chemicals stabilized dimeric forms of the haemagglutinin (HA) or fusion (F) proteins, although by sucrose density gradient analysis, oligomers corresponding to tetramers and larger were observed for both proteins. In cells in which both HA and F were expressed at the surface, their close association was shown by cross-linking and co-immunoprecipitation.

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页码：2365 / 2372

页数：8

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