CISPLATIN BLOCKS VOLTAGE-DEPENDENT CALCIUM CURRENT IN DISSOCIATED OUTER HAIR-CELLS OF GUINEA-PIG COCHLEA

被引：16

作者：

YAMAMOTO, T

KAKEHATA, S

SAITO, T

SAITO, H

AKAIKE, N

机构：

[1] FUKUI MED SCH,DEPT OTOLARYNGOL,FUKUI,JAPAN

[2] TOHOKU UNIV,SCH MED,DEPT OTOLARYNGOL,SENDAI,JAPAN

来源：

BRAIN RESEARCH | 1994年 / 648卷 / 02期

关键词：

OUTER HAIR CELL; GUINEA PIG; CISPLATIN; OTOTOXICITY; CALCIUM CURRENT; WHOLE-CELL VOLTAGE CLAMP;

D O I：

10.1016/0006-8993(94)91130-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the ototoxic molecule cisplatin (cis-DDP) on the voltage-dependent Ca2+ channel in dissociated outer hair cells (OHCs) of guinea-pig cochlea was investigated using a whole-cell patch-clamp technique. Cis-DDP had antagonistic effect on the Ca2+ channel and reversibly suppressed the Ca2+ current in a concentration-dependent manner. These results suggested that one of the ototoxic mechanisms of cis-DDP is involved in the inhibition of the Ca2+ channel in OHCs.

引用

页码：296 / 298

页数：3

共 17 条

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