IMMUNOREACTIVITY PATTERNS IN NEUROFIBRILLARY TANGLES OF THE INFERIOR TEMPORAL CORTEX IN ALZHEIMER-DISEASE

被引：11

作者：

DUONG, TH

GALLAGHER, KA

机构：

[1] Indiana University School of Medicine, Terre Haute Center for Medical, Education at Indiana State University, Terre Haute, 47809, IN

来源：

MOLECULAR AND CHEMICAL NEUROPATHOLOGY | 1994年 / 22卷 / 02期

关键词：

AMYLOID P COMPONENT; MICROTUBULE-ASSOCIATED PROTEINS; TAU; NEUROFIBRILLARY TANGLE; NONPHOSPHORYLATED NEUROFILAMENTS; UBIQUITIN;

D O I：

10.1007/BF03160099

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distributions of various immunohistochemical markers of neurofibrillary tangles (NFT) were compared to that of a normal nerve cell cytoskeletal marker, SMI32, in the inferior temporal cortex of Alzheimer brains and normal aged controls. NFT markers included antibodies to the microtubule-associated proteins tau, ubiquitin, or amyloid P component (AP). The results showed that, in our group of patients, the decrease of SMI32 immunoreactivity in the Alzheimer temporal cortex is paralleled by an increase in AP immunoreactivity in neurons and neurofibrillary tangles. This suggests that AP may play an important role in NFT formation or evolution in Alzheimer disease.

引用

页码：105 / 122

页数：18

共 40 条

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