HUMAN METALLOTHIONEIN GENES - STRUCTURE OF THE FUNCTIONAL LOCUS AT 16Q13

被引：170

作者：

WEST, AK

STALLINGS, R

HILDEBRAND, CE

CHIU, R

KARIN, M

RICHARDS, RI

机构：

[1] UNIV CALIF LOS ALAMOS SCI LAB,DIV LIFE SCI,GENET GRP,LOS ALAMOS,NM 87544

[2] UNIV CALIF SAN DIEGO,SCH MED,LA JOLLA,CA 92093

[3] ADELAIDE CHILDRENS HOSP INC,DEPT HISTOPATHOL,CYTOGENET UNIT,ADELAIDE,SA 5006,AUSTRALIA

来源：

GENOMICS | 1990年 / 8卷 / 03期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

D O I：

10.1016/0888-7543(90)90038-V

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The functional human metallothionein (MT) genes are located on chromosome 16q13. We have physically mapped the functional human MT locus by isolation and restriction digest mapping of cloned DNA. The mapped region contains all sequences on chromosome 16 that hybridize to metallothionein gene probes and comprises 14 tightly linked MT genes, 6 of which have not been previously described. This analysis defines the genetic limits of metallothionein functional diversity in the human genome. © 1990.

引用

页码：513 / 518

页数：6

共 28 条

[11] HUMAN METALLOTHIONEIN GENES - MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF THE MESSENGER-RNA [J].